I’ve been meaning to post this Time article for a while. It covers a wide variety of topics but is centered around the “recent discoveries” that the human brain is amazingly adaptive. For example, changing the way you think literally alters your brain chemistry. The article also explores a few of the methods that people have successfully used to rewire their brains (including meditation) and it makes mention of anxiety disorders and depression. As time passes and the research continues to pile up, the “anxiety is a disease” camp grows ever smaller. Research has consistently shown that most forms of anxiety and depression can be effectively treated with a shotgun approach that includes cognitive therapy, medications, and meditation or other forms of “brain rewiring.” In other words, there’s nothing fundamentally wrong with you.
The whole “chemical imbalance” stuff is a misinterpretation of the data. It’s your anxiety that causes the imbalance, not the other way around. Your serotonin and noradrenaline problems are real and medication can treat them, but treating the imbalance by itself is only treating the symptons and not the causes of your anxiety and/or depression; therefore, such treatment is only part of the solution.
At the risk of going off on a tangent about my own personal bias for such approaches, I’ll just let you read the article and decide for yourself. Here’s an excerpt:
FOR DECADES, THE PREVAILING DOGMA IN neuroscience was that the adult human brain is essentially immutable, hardwired, fixed in form and function, so that by the time we reach adulthood we are pretty much stuck with what we have. Yes, it can create (and lose) synapses, the connections between neurons that encode memories and learning. And it can suffer injury and degeneration. But this view held that if genes and development dictate that one cluster of neurons will process signals from the eye and another cluster will move the fingers of the right hand, then they’ll do that and nothing else until the day you die. There was good reason for lavishly illustrated brain books to show the function, size and location of the brain’s structures in permanent ink.
[...]
But research in the past few years has overthrown the dogma. In its place has come the realization that the adult brain retains impressive powers of “neuroplasticity”–the ability to change its structure and function in response to experience. These aren’t minor tweaks either. Something as basic as the function of the visual or auditory cortex can change as a result of a person’s experience of becoming deaf or blind at a young age. Even when the brain suffers a trauma late in life, it can rezone itself like a city in a frenzy of urban renewal. If a stroke knocks out, say, the neighborhood of motor cortex that moves the right arm, a new technique called constraint-induced movement therapy can coax next-door regions to take over the function of the damaged area. The brain can be rewired.
Don’t just sit there. Read this! This new way of thinking about the brain is already beginning to make waves among psychiatrists and psychotherapists. Your doctor is following this stuff and so should you.


6 comments
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February 21, 2007 at 7:41 am
oldude59
Your concern for the anxious I get. The same could be said for addictions - my concern. The problem I sense in your formulation is that in a strange way it kind of echoes “Moral failure” If you can change your brain’s mechanics by thinking other stuff then if you are addicted then all you have to do is think other stuff - right? Wrong!! It may mean at some point the path ways can and contributions of brain chemicals can be moved around - but the life and genetics that conspire to produce the platform for use dependence has not changed.
I get that taking control of or responsibility for is important for both the anxious and addicted - they are more than likely one and the same, but for know they have different styles of problems to overcome. I think you for pointing out the article - I agree with your insight, but caution for patience in your directive.
February 21, 2007 at 8:12 am
Cindy
Josh - an excellent article! Thanks for posting it, I hardly ever read Time magazine so I missed that!
I think one of the big problems or issues in treatment and discussion of Anxiety is that many people use one word to cover a myriad of symptoms and cross-diagnosed illnesses. While anxiety may not be a disease but a symptom, there are defintely organic brain disorders and diseases that can exhibit symptoms similar to Depression and Anxiety that are correctly treated with medication, and taken seriously as a disease.
But I don’t think we are saying different things. Even those suffering Clinical Depression, Schizophrenia and Bi-Polar Disorder (as opposed to Panic or Anxiety Disorder) benefit from a multi-faceted approach to healing that includes changes in diet, increased exercise, guided meditation, talk and other therapy, as well as closely monitored medication.
And in my experience with addiction (to address the post above) there are many, MANY people in recovery from Alcohol and Substance Abuse who also suffer from disorders and diseases that must and should be treated with medication. Very rarely is life so simple that only one “name” can cover all bases. There does not have to be a “moral” implication. Suffering and healing are human processes, common to most everyone in one way or another.
People who suffer can, and I believe should, be engaged at multiple levels in their own healing. Choices, practice, progress and reinforcement can assist sufferers to make the hardest changes ever — the change in the way they have always done something. Not moralizing “oh you’re just wrong” but encouraging and supportive - “yes, you can change.”
February 21, 2007 at 9:23 am
Josh
That’s a common oversimplification. You can’t change your brain by “thinking other stuff.” As far as I know, that won’t do you much good. You’re referring to something like positive affirmations, which may be helpful but it isn’t a solution. Changing your thoughts is NOT EQUAL TO thinking other stuff. You’d just be swapping one bad habit for another.
I don’t think that anxiety, depression, or addiction are “moral failures” by any stretch. They’re a part of the human condition and, as such, most of us will deal with one or all of them at some point in our lives. Yet the research is consistent: we are, by and large, in control of how we feel about ourselves and world around us. And it isn’t just modern research. There are spiritual traditions over one thousand years old which have known and taught this very same principle. This isn’t new stuff here.
Regardless, turning ourselves into victims does absolutely nothing to help relieve our pain and, if anything, it only prolongs it.
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oldude59 said:
Your concern for the anxious I get. The same could be said for addictions - my concern. The problem I sense in your formulation is that in a strange way it kind of echoes “Moral failure” If you can change your brain’s mechanics by thinking other stuff then if you are addicted then all you have to do is think other stuff - right? Wrong!! It may mean at some point the path ways can and contributions of brain chemicals can be moved around - but the life and genetics that conspire to produce the platform for use dependence has not changed.
I get that taking control of or responsibility for is important for both the anxious and addicted - they are more than likely one and the same, but for know they have different styles of problems to overcome. I think you for pointing out the article - I agree with your insight, but caution for patience in your directive.
February 23, 2007 at 12:29 am
Social Avoidance
This is a great blog, lots of information. The article is excellent, I’m on the side of believing is possible to deal with anxiety, we just need to find our own way, I mean we have to recognize our own potentials and weaknesses to accomodate our lifes. I also agree, medicines are great and they really help, but without therapy, better lifestyle, spirituality, we are not going to make it easy for our lifes.
February 25, 2007 at 9:31 am
Sonya
Thanks for this article, Josh. It gives me hope for the future treatment of our disorders. I certainly agree with your last comment - too many people are content to play the ‘victim’ and carry their illness forever. I don’t believe in that - we CAN change, but we have to WANT to.
May 9, 2007 at 11:05 am
BOB FIDDAMAN
A Chemical Imbalance
Neither GlaxoSmithKline or the MHRA can give answers as to what constitutes a proper chemical imbalance of serotonin in the brain - weird because Seroxat is prescribed for this ‘disorder’
The only thing that I can see is that Seroxat actually causes the chemical imbalance rather than rectifies it - A genius piece of marketing by GSK.
Prescribe a drug
Let the patient get hooked on the drug
Play down the risks by producing clinical trial studies beneficial to GSK
Employ ghost writers and patient support groups to back up the benefits of taking Seroxat
Robustly deny Seroxat causes aggression, suicidal tendancies etc
Always settle out of court for any litigation
Infiltrate the Medicines Regulatory Agency with former employees of GSK
Fund the government
Financially secure to research and market more SSRi type drugs
Credit where it is due, the marketing team at GlaxoSmithKline are without doubt highly skilled at manipulating doctors and the general public.
They don’t even klnow how Seroxat works - they are just pleased that it does work. Cases where it hasn’t worked - infact quite the reverse, seem to go unoticed - until the invention of the internet that is.
The MHRA are proud of the Yellow Card system - Why?
It is a completely flawed system and they only act on less than half of the Yellow Card reports.
A more robust system would be for the MHRA to employ a person or persons with a basic grasp of internet seaching. Then, they will see the REAL suffering from the REAL people.
Alas, they have ties to GlaxoSmithKline, namely Alistair Breckenridge and Ian Hudson. If they see GlaxoSmithKline have duped the public then they themselves have been duped by messrs Breckenridge and Hudson and that would cast a serious dark shadow on the MHRA’s integerity.
They (The MHRA) have been investigating GlaxoSmithKline for nigh on four years now - my guess is they are waiting for a ‘busy news day’ until they release their findings. This way the story will be pushed to some small article in the tabloids.
It is utterly shameful of any human being to cause human suffering. Both GlaxoSmithKline and The MHRA have continued to deny Seroxat is harmful in the adult population - forget the clever spin ‘dangerous in young adults’.
GlaxoSmithKline are currently being sued through the courts both here in the UK and in the United States. It now needs a firm of solicitors with huge balls to sue the MHRA. There is enough evidence I’m sure to successfully bring them to trial.
It will happen
Bob
Seroxat Sufferers
http://fiddaman.blogspot.com